The Billionaire's Runaway Maid follows Iris, a humble small-town girl who enters a secret marriage with Dominic Hale, a powerful billionaire CEO, after saving his grandfather's life. While hiding her identity as his wife at work, she faces intense workplace bullying and false accusations from jealous colleagues until Dominic steps in to fiercely protect her and punish her tormentors. However, driven by escalating misunderstandings and scheming antagonists, Iris discovers she is pregnant and decides to flee, triggering a frantic search by Dominic who eventually uncovers the truth, dismantles the lies, and wins back his hidden wife for a happy ending.