Researchers at Rockefeller University have identified that diminished levels of arginine impair immune responses by lowering the production of MHC-1, an essential cellular alert signal. In conditions of low arginine availability, ribosomes experienced delays in synthesizing MHC-1, leading to 414 proteins being present at notably reduced levels in cells lacking arginine. A moderate intake of arginine, comparable to the amount found in a few common over-the-counter supplements, reinstated MHC-1 gene activity. Mice on arginine-rich diets exhibited fewer colon tumors, while those receiving arginine post-influenza infection demonstrated better health outcomes. The study published in Cell highlights that arginine levels naturally decline with age.
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