Scientists from Rockefeller University have identified that diminished levels of arginine, a prevalent amino acid, can interfere with the synthesis of MHC-I proteins, which are crucial for T cells in identifying cancerous and virus-infected cells. Experiments conducted on mice demonstrated that diets rich in arginine reinstated MHC-I production, curtailed the growth of colon tumors, and alleviated symptoms associated with influenza and SARS-CoV-2 infections. This investigation assessed 414 proteins influenced by arginine deficiency, with those related to MHC-I being particularly notable. The results, published in Cell, have the potential to guide future cancer and antiviral treatment strategies, though further clinical trials are essential to ascertain their applicability to humans.
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